HCN Channels and Heart Rate
نویسندگان
چکیده
منابع مشابه
HCN channels and heart rate.
Hyperpolarization and Cyclic Nucleotide (HCN) -gated channels represent the molecular correlates of the "funny" pacemaker current (I(f)), a current activated by hyperpolarization and considered able to influence the sinus node function in generating cardiac impulses. HCN channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channe...
متن کاملQuickening the Pace Looking into the Heart of HCN Channels
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to a wide range of physiological functions and regulate cardiac and neuronal pacemaker activity. Here, we review recent advances in three areas: the polarity of the S4 movement with hyperpolarization, the location of the activation gate, and the structure of the C-terminal C linker and CNBD.
متن کاملcAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.
BACKGROUND HCN channels activate the pacemaker current I(f), which is thought to contribute significantly to generation and regulation of heart rhythm. HCN4 represents the dominant isotype in the sinoatrial node and binding of cAMP was suggested to be necessary for autonomic heart rate regulation. METHODS AND RESULTS In a candidate gene approach, a heterozygous insertion of 13 nucleotides in ...
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H eart failure (HF) affects ≈2% to 3% of the population in many industrialized countries 1 and is a major cause of mortality. Although widely used treatments such as β-blockers and renin-angiotensin system antagonists have largely improved outcomes in the past 2 decades, prognosis remains poor. Accumulating data collected in >200 000 individuals in various epidemiological studies support that a...
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The amount of neurotransmitter stored in synaptic vesicles determines postsynaptic quantal size and thus the strength of synaptic transmission. However, little is known about regulation of vesicular neurotransmitter uptake. In recordings from the calyx of Held, a giant mammalian glutamatergic synapse, we found that changes in presynaptic Na(+) concentration above and below a resting value of 13...
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ژورنال
عنوان ژورنال: Molecules
سال: 2012
ISSN: 1420-3049
DOI: 10.3390/molecules17044225